The research mission of the Division of BioAnalytical Chemistry is to design, understand and apply novel and improved analytics in order to gain new and better insights into biomolecular and drug characteristics, and biological and chemical processes. Our research is directed towards methodological innovation and increased information content to solve life science queries. Focus is on advanced sample preparation and separation techniques in combination with state-of-the-art mass spectrometry, optical spectroscopy and bio-activity detection. Hyphenation, integration, miniaturization and automation, are important aspects to face demands on selectivity, sensitivity, speed and data handling.
The Division of BioAnalytical Chemistry is consists of two chairs: Biomolecular Analysis and Analytics of Biomolecular Interactions.
The Biomolecular Analysis research group of Prof. Govert Somsen is focused on the development of novel analytical methodologies for the characterization, discovery and trace analysis of biologically active compounds. The three main areas of interest are:
- Compositional and conformational characterization of intact biomacromolecules using highly selective separation in combination with high-resolution (tandem) mass spectrometry and optical spectroscopy.
- Development and application of high-resolution screening technologies enabling the simultaneous probing of bio-activity and chemical characterization of components in complex samples.
- Targeted and untargeted metabolite analysis in biofluids with particular attention for metabolite chirality.
- Dr. Jeroen Kool: Bioactivity Screening Technologies
Analytics of Biomolecular Interactions
The Analytics of Biomolecular Interactions research group of Prof. Manfred Wuhrer is devoted to the development of mass spectrometric techniques in glycomics and glycoproteomics. These techniques – together with other types of “omics” techniques – are applied to clinical biomarker discovery as well as to the characterization of biopharmaceuticals. Wuhrer’s group also studies the interaction of glycans and glycoconjugates with various cellular receptors and antibodies using microarray technology.
The following subgroup is associated with this chair:
- Dr. Henk Lingeman: Bio-analysis: Sample pretreatment and separation methods