Division of Organic Chemistry

Research profile

Romano Orru   Tom Grossmann      

Prof. dr. ir. Romano Orru          Prof. dr. Tom N. Grossmann

The Division of Organic Chemistry consists of two chairs: Synthetic & Bio-organic Chemistry, and Organic and Peptide Chemistry. 

Synthetic & Bio-organic Chemistry

The Synthetic & Bio-organic Chemistry research group of Prof. Romano Orru focuses on the development of highly efficient, asymmetric synthetic methodologies and their application to the synthesis of diverse, biologically relevant compounds, with an emphasis on atom and resource efficiency. Three main areas of interest can be distinguished:

  • Rational design and development of flexible novel multicomponent reactions (MCRs).

  • Use of biocatalysts for the production of enantiopure building blocks for MCR.

  • Development of asymmetric versions of MCRs and related processes using biocatalysis and/or homogeneous catalysis. 

The group's efforts in this area have resulted in the development of several novel MCRs furnishing valuable heterocycles. Another goal is the integration of the group’s successes in MCR chemistry and biocatalysis in approaches towards the total synthesis of complex natural products.

The following subgroups are associated with this chair: